Vitamin B complex and magnesium are important factors for the treatment of depression. Patients with depression was low in folic acid and other vitamins causes’ depression. The optimum level of Vitamin B complex and Magnesium are the good treatment of depression. Magnesium is involved in more than 300 reactions in body and it’s shortage in body causes depression and diabetes and many other illnesses. Different seeds, nuts and vegetables are good source of magnesium.