Tag Archives: DNA

“The story of DNA continues to twist and turn”!

Scientists Discover Quadruple Helix: Four Strand DNA In Human Cells

by Arjun

The human race knows very little of itself, almost like a race with amnesia. As we continue to move forward through time, new discoveries are made that make old theories obsolete and false. It’s a good lesson that shows us how we can attach ourselves to “truths” and believe them whole-heartedly, often forgetting that truth is constantly changing and new paradigms of perception always lurk around the corner.

Decades after scientists described our “chemical code” of life using the double helix DNA, researchers have discovered four-stranded DNA within human cells. The structures are called G-quadruplexes, because they form in regions of DNA that are full of guanine, one of the DNA molecule’s four building blocks. The others are adenine, cytosine and thymine. A hydrogen bond is responsible for holding the four guanines together. The four stranded DNA usually presents itself right before cell division.

The discovery was published online in Nature Chemistry, and you can take a look at it here. The study was led by Shankar Balasubramanian at the University of cambridge, UK.

For us, it strongly supports a new paradigm to be investigated – using these four-stranded structures as targets for personalized treatments in the future.We have found that by trapping the quadruplex DNA with synthetic molecules we can sequester and stabilise them, providing important insights into how we might grind cell division to a halt — Shankar Balasubramanian

The study went on to show certain links between concentrations of four-stranded G-quandruplexes and the process of DNA replication, which is crucial to cell division and cell production. G-quadruplexes, (when targeted with synthetic molecules responsible for trapping and holding these DNA structures) prevent cells from replicating their DNA, thus blocking cell division. Scientists believe that this discovery could possibly lead to a stop in cell proliferation at the root of cancer ….

Read more » Collective Evolution
http://www.collective-evolution.com/2013/07/17/scientists-discover-quadruple-helix-four-strand-dna-in-human-cells/

Via – Facebook

Rape cases: Sindh Assembly calls for mandatory DNA tests

By: Daily Dawn Report

KARACHI: The Sindh Assembly has unanimously passed a resolution which calls for making DNA tests mandatory in rape cases. The resolution was tabled by PPP MPA Sharmila Farooqi.

As per the resolution, DNA tests should be mandatory in all rape cases, the costs of which should be supported by the Sindh government.

The resolution comes in the wake of controversial recomendation by the Council of Islamic Ideology (CII) last month which had attracted a great deal of criticism from women rights organisations.

The CII had recommended that DNA should not be included as a primary evidence with regard to rape cases.

They held the view that Islam has set procedures to determine cases of rape and said Islamic procedure should be adopted during investigation.

The Human Rights Commission of Pakistan (HRCP) had called the CII declaration “regressive, unfortunate and unkind to rape victims.”

The HRCP also called on the new government for an urgent reconstitution of the CII.

A number a civil society groups have called for the CII to be abolished in the ‘larger interest of a progressive and tolerant society’.

Courtesy: DAWN
http://beta.dawn.com/news/1017553/rape-cases-sindh-assembly-calls-for-mandatory-dna-tests

The arrest of Dr Fai, may appear as isolated legal action of the US government but the scratch below the surface is just the beginning of the US retribution against Pakistani actions

On the course of retributions

By Dr. Manzur Ejaz | DAWN.COM

The arrest of Dr Ghulam Nabi Fai, and arrest warrant of a Pakistani national, Zaheer Ahmad, may appear as isolated legal actions of the US government against its citizens for unauthorised lobbying for Pakistan. However, scratch below the surface and it becomes clear that this is just the beginning of the US retribution against Pakistani actions.

The matter has been brewing and coming to the boiling point since Raymond Davis’ arrest and then jailing of those who helped the US in nabbing Osama bin Laden. In recent days, the US media has been reporting that the US is pressuring Pakistan for the releasing of Dr Shakil Afridi who was reported to be arrested for undertaking a fake vaccination campaign to get blood samples of bin Laden’s kids for DNA match.

Every Washington circle that had anything to do with Pak-American-Kashmir affairs was well aware of Dr Fai’s activities in the community, think tanks and on lobbying with Congress and Senate members. Most activists among the Pakistani-American community have been speculating about Dr Fai’s connection with Pakistani government and/or Inter Services Agency (ISI). Therefore, the allegation of having received about four million dollars from Pakistan and making over four thousand phone calls to his alleged handlers from ISI will not be totally perceived as concocted charges even among Pakistani expatriates. Pakistan embassy’s claim that Dr Fai is not a Pakistani citizen—he came from India and sought amnesty in the US—is not going to lessen the impact of such a damaging development.

Dr Fai’s activities on the Capital Hill and his arrangements of large and expensive conferences involving key people from Pakistan and India were quite open. It can be safely assumed that he was giving heart burns to Indian diplomats and lobbyists and they must have been pressurising the US government to rein him in. However, the US had chosen to look the other way for a decade and never bothered with his activities. But, now the parameters have changed. Probably because the US wants to send the message that it has some options to retaliate in Pakistani style as well.

It is well known that Pakistan has its own human intelligence assets in the US. Of course such assets must be a fraction of what a sole world superpower, the US, would have in Pakistan. The US financial power to buy human assets in Pakistan, Europe and from the rest of the world cannot be matched by a poor developing country. Nonetheless, the party with meager resources gets hurt more when mutual retributions occur.

Before Dr Fai’s arrest Washington’s diplomatic circles were subtly pointing out for such retribution. According to very reliable sources, the US side was arguing with Pakistani diplomats that millions of Pakistani-Americans live in America—some of them are Green Card Holders and technically, Pakistani nationals—and the US issues hundreds of thousands of student, visiting, business and work visas to Pakistanis while Pakistan is raising questions about a few hundred visas.

A thinly veiled threat is that if Pakistan continues restricting movements of its diplomats and citizens, the US can do the same putting Pakistani diplomats’ work in jeopardy and creating problems for visitors. Technically, the US can cancel Green Cards on very flimsy grounds, through finding any trivial fault with application process, and send thousands of Pakistanis back home. It is not very likely to happen but if things get too far it is not out of question either.

If the US expands the scope of retributions the diplomatic make-up of staff at Pakistani embassy may change as well. Pakistan may not be able to appoint ranking officials from intelligence agencies as ‘head of community affairs’ or under other such covers. The set of military mission in the embassy may be realigned as well. Most of all, the US agencies, particularly tax authorities, can be used to scare prosperous Pakistanis, mostly physicians, who hold fund raisers for the US lawmakers and arrange their meeting with Pakistani diplomats and incoming Pakistani officials. Such moves will certainly hamper little efforts Pakistani-Americans make to provide bridge between the two countries.

If the negative perception of Pakistan further deepens, the US may not be able to use drones in Pak-Afghan border areas but it will hit Pakistan’s financial system with stealth bombers. Besides stopping the financial aid, the US can harm Pakistan’s foreign currency earnings by creating difficulties for transmitting the remittances of Pakistani expatriates. Presently, Pakistani expatriates contribute a significant portion of foreign remittances of Pakistan. Furthermore, it can issue guidance to donor agencies, European partners and other private financial institution to hold back on financial transfers to Pakistan.

A sketch of broad possible scenarios of US retribution–been started with Dr Fai’s arrest–is not to scare the new found patriotism in Islamabad. Patriotic feelings are very noble, worthy and respectable but one should know the cost as well. Before throwing stones at others while sitting in the glass houses, one should have thick tall walls to protect oneself. Are Islamabad and GHQ ready to build such walls if the US process of retributions expands? Does not seem like it.

Courtesy: → DAWN.COM