Scientists Discover Quadruple Helix: Four Strand DNA In Human Cells
The human race knows very little of itself, almost like a race with amnesia. As we continue to move forward through time, new discoveries are made that make old theories obsolete and false. It’s a good lesson that shows us how we can attach ourselves to “truths” and believe them whole-heartedly, often forgetting that truth is constantly changing and new paradigms of perception always lurk around the corner.
Decades after scientists described our “chemical code” of life using the double helix DNA, researchers have discovered four-stranded DNA within human cells. The structures are called G-quadruplexes, because they form in regions of DNA that are full of guanine, one of the DNA molecule’s four building blocks. The others are adenine, cytosine and thymine. A hydrogen bond is responsible for holding the four guanines together. The four stranded DNA usually presents itself right before cell division.
The discovery was published online in Nature Chemistry, and you can take a look at it here. The study was led by Shankar Balasubramanian at the University of cambridge, UK.
For us, it strongly supports a new paradigm to be investigated – using these four-stranded structures as targets for personalized treatments in the future.We have found that by trapping the quadruplex DNA with synthetic molecules we can sequester and stabilise them, providing important insights into how we might grind cell division to a halt — Shankar Balasubramanian
The study went on to show certain links between concentrations of four-stranded G-quandruplexes and the process of DNA replication, which is crucial to cell division and cell production. G-quadruplexes, (when targeted with synthetic molecules responsible for trapping and holding these DNA structures) prevent cells from replicating their DNA, thus blocking cell division. Scientists believe that this discovery could possibly lead to a stop in cell proliferation at the root of cancer ….
Via – Facebook
By DECLAN WALSH
ISLAMABAD, Pakistan – The high-stakes battle between Pakistan’s judiciary and government took a fresh twist on Thursday when a court issued an arrest warrant for a close ally of President Asif Ali Zardari, effectively blocking his nomination as the country’s next prime minister.
Mr. Zardari wanted Makhdoom Shahabuddin, a former health minister from Punjab Province, to replace Yousaf Raza Gilani, who was dismissed as prime minister by the Supreme Court on Wednesday.
But hours after Mr. Shahabuddin’s nomination, a magistrates court, prompted by the military-run Anti-Narcotics Force, ordered his arrest to face charges relating to the illegal production of a controlled drug two years ago.
The court also issued an arrest warrant for Ali Musa Gilani, a son of the outgoing prime minister, in relation to the same case.
The ruling party Pakistan Peoples Party quickly nominated a new candidate, former information minister Qamar Zaman Kaira, who now looks likely to become the prime minister after a vote in parliament on Friday.
The dramatic court manoeuver highlights the growing difficulty of separating law from politics in the country’s rapidly evolving machinations of power.
Mr. Zardari’s supporters, and some analysts, say judiciary is using its widening powers to erode the authority of the government and ultimately push it from power. “Absolutely no subtlety anymore in going after the govt. Amazing,” wrote Nadeem F. Paracha, a newspaper columnist, on Twitter.
HYDERABAD, Feb 8: The tug of war between the vice-chancellor and teachers of Sindh University took a new twist on Tuesday night when a syndicate meeting at the Governor House in Karachi decided to terminate the services of two teachers’ leaders and suspend six others. Although the university authorities have not yet issued any notification, sources told Dawn ….
Read more » DAWN.COM
Pakistan scandal’s latest twist: naked wrestling
By CHRIS BRUMMITT
The Associated Press – ISLAMABAD : A scandal over a secret memo to Washington that could bring down the Pakistani president took a strange turn Wednesday when a music video surfaced featuring the chief accuser acting as a commentator for a naked female wrestling bout.
Opponents of Mansoor Ijaz, an American of Pakistani origin, said the clip damaged his credibility ahead of his scheduled appearance at a Supreme Court commission in this conservative Muslim country. The Florida-born businessman has pledged to provide damning evidence that the Pakistani government sent the note seeking U.S. help preventing a military coup in the aftermath of the American raid that killed Osama bin Laden on May 2, 2011.
Others were simply amused at the latest twist in an affair that has transfixed the media and raised tensions between the government and the powerful military to dangerous levels. Dubbed “memogate” in the Pakistani media, one Twitter user suggested it should now be renamed “booty-gate.”
Ijaz, who boasts of close friendships with the U.S. security establishment and past back-channel diplomatic roles in Sudan and Kashmir, claims the unsigned memo was authored by the then-Pakistan envoy to Washington, Husain Haqqani.
Ijaz says that at Haqqani’s request, he delivered the memo to Adm. Mike Mullen, the top U.S. military officer at the time. Mullen’s spokesman confirmed that his boss did receive the memo from Ijaz but that he did not find it credible and ignored it.
Haqqani denied any role in the memo but resigned last year amid pressure from the outraged military. Ijaz has said that he gave computer records implicating Haqqani to Pakistan’s spy chief, Lt. Gen. Shuja Pasha, who he says flew to London to meet with him in October. Pasha has told the court that he found the evidence credible.
The country’s top court is now probing the affair, which some believe could result in treason charges against Haqqani. President Asif Ali Zardari could also be vulnerable if — as Ijaz’s lawyer claims — it can be proven he also knew about the note. The investigation comes as Pakistani-U.S. relations are at an all-time low.
It was unclear why the wrestling video, which was made in 2004 and has been viewed for years on the Internet, came to light only now. Ijaz’s role was apparently spotted by a blogger late Tuesday and spread quickly through social media.
Ijaz told The Associated Press he thought the video’s emergence was part of an effort by Haqqani to discredit him ahead of his testimony but conceded he had no evidence of this. He confirmed that the video was not a hoax. ….
Read more » AJC.COM
Life Bridge is a registered nonprofit organization. Life Bridge Pakistan Trust, registered under the social welfare act of Pakistan. Life Bridge’s mission and message is one of peace and a brotherhood bound by humanity.
After having been raised in America, Dr. Geeta Chainani’s identity as a Sindhi brought her back to Pakistan in search of her family history. An unexpected twist of fate brought her face to face with what is now being termed as the “greatest natural disaster of our time” – the massive flooding that began on July 29, 2010.
After witnessing the great burden of disease whose victims mainly consisted of women and children Dr. Chainani decided to dedicate the rest of her trip to providing emergency medical care in two tent cities.
Confronted with the humanitarian crisis of “epic proportions” present following the floods and the Sindhi diaspora’s increasing interest in her work in Pakistan Dr. Chainani realized she was the only one to bridge this divide. Life Bridge was founded as that bridge, hence it’s name.
Since Sept 2, 2010, Dr. Chainani continues to provide life-saving services in the villages of rural Sindh. Together, Team Life Bridge US and Team Life Bridge Pakistan work to bridge the gaps in issues related to: Health, Water, Sanitation and Hygiene, Shelter, Food. For more visit » http://www.thelifebridge.us
- Heroic Tale of Holocaust, With a Twist
By ELAINE SCIOLINO
PARIS — The stories of the Holocaust have been documented, distorted, clarified and filtered through memory. Yet new stories keep coming, occasionally altering the grand, incomplete mosaic of Holocaust history.
One of them, dramatized in a French film released here last week, focuses on an unlikely savior of Jews during the Nazi occupation of France: the rector of a Paris mosque.
Muslims, it seems, rescued Jews from the Nazis.
“Les Hommes Libres” (“Free Men”) is a tale of courage not found in French textbooks. According to the story, Si Kaddour Benghabrit, the founder and rector of the Grand Mosque of Paris, provided refuge and certificates of Muslim identity to a small number of Jews to allow them to evade arrest and deportation.
It was simpler than it sounds. In the early 1940s France was home to a large population of North Africans, including thousands of Sephardic Jews. The Jews spoke Arabic and shared many of the same traditions and everyday habits as the Arabs. Neither Muslims nor Jews ate pork. Both Muslim and Jewish men were circumcised. Muslim and Jewish names were often similar.
The mosque, a tiled, walled fortress the size of a city block on the Left Bank, served as a place to pray, certainly, but also as an oasis of calm where visitors were fed and clothed and could bathe, and where they could talk freely and rest in the garden. …
Read more → The New York Times
Laada with a twist. An energetic performance by Sindhi youngsters of Dubai. Performed at Sindhyat Jee Mauj, a grand evening of Sindhi music, dance and comedy. Singer: Koshi Lalwani, Album: Nach Nach, Event Organized by: Asha Chand, Choreographer: Poonam Kateja.
- You Tube
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Protesters halt Pakistani PM court case – BBC
The trial of Pakistan’s Prime Minister, Nawaz Sharif, has been halted after his supporters forced their way into the Supreme Court building in Islamabad.
Protesters shouted abuse against the Chief Justice, Sajjad Ali Shah, who was hearing a case of contempt of court, which could lead to the Prime Minister’s disqualification if he is found guilty. The court adjourned for the day.
The protest is the latest twist in the country’s constitutional crisis, which started over the appointment of five new judges to the Supreme Court.
Mr Ali Shah charged Mr Sharif with contempt after his outspoken criticism of the candidates. Mr Sharif responded by trying to remove him from office.
The two men are under considerable pressure from the country’s powerful armed forces to resolve the situation constitutionally.
Mr Ali Shah’s position in the court has become increasingly uncertain after an internal struggle emerged in the Supreme Court over his status. Four of his fellow judges in two separate hearings ruled he was suspended from office because he was not the most senior judge when he was appointed.
Friday’s trouble started when one of Mr Sharif’s Members of Parliament climbed over the gates in front of the court to get inside.
A crowd of a few hundred party supporters then began to follow him and, as the police and the security forces in riot gear stood by and did nothing, they pushed open the gates and ran into the court compound.
A few members of the crowd got into the court building and ran to windows and onto the roof of the entrance, chanting slogans against the Chief Justice.
Amid the commotion a court official ran to the courtroom and said the Chief Justice was in danger. The judges immediately adjourned proceedings and left the room.